Twin Rivers Physical Therapy & Wellness in Clarkston is pleased to share information about peptide-supported recovery protocols that we are now able to offer our community through a licensed medical partner and FDA-registered 503A/503B compounding pharmacies.
As a rehabilitation-focused practice, we are continually seeking thoughtful, evidence-informed ways to support tissue healing, inflammation modulation, and functional recovery—particularly for patients navigating post-operative or musculoskeletal rehabilitation. These peptide protocols are intended to serve as adjunctive support to standard medical and surgical care, not as replacements.
Enclosed, you will find an overview of some of the most sought-after protocols currently being utilized, including those designed to support soft-tissue healing, connective tissue integrity, and post-procedural recovery.
We value collaboration and transparency and are happy to provide additional information, literature references, or answer any questions you or your team may have.
Our goal is to complement the excellent care already being provided and to support patients in achieving the best possible recovery outcomes.
Thank you for the care you provide to our shared community.
Twin Rivers PT & Wellness partners with a licensed medical clinic and FDA-registered 503A/503B compounding pharmacies to offer peptide-supported recovery protocols designed to complement standard medical and surgical care. These protocols focus on supporting soft-tissue healing, inflammation modulation, and post-procedural recovery.
These therapies are not intended to replace established medical or surgical treatment, but to support physiologic recovery processes under licensed medical oversight.
WOLVERINE PROTOCOL (BPC-157 + TB-500)
Adjunctive Indications:
- Post-operative orthopedic recovery
- Tendon, ligament, and soft-tissue injury
- Chronic musculoskeletal inflammation
- Delayed tissue healing
BPC-157 (Body Protection Compound)
A synthetic pentadecapeptide derived from a naturally occurring gastric peptide. Preclinical studies demonstrate support for angiogenesis, fibroblast migration, tendon-to-bone healing, and inflammatory modulation.
TB-500 (Thymosin Beta-4 fragment)
A synthetic fragment of thymosin beta-4 involved in actin regulation and cell migration. It supports tissue remodeling, cellular repair, and recovery following injury or surgery.
Clinical Rationale:
The combined use of BPC-157 and TB-500 is intended to support soft-tissue repair, reduce inflammatory burden, and improve functional recovery timelines—particularly in orthopedic and sports medicine recovery settings.
GLOW PROTOCOL (BPC-157 + TB-500 + GHK-Cu)
Adjunctive Indications:
- Post-surgical recovery
- Connective tissue and collagen support
- Inflammatory modulation
- Skin and tissue integrity
- GHK-Cu (Copper Tripeptide-1)
A naturally occurring human peptide with extensive research supporting its role in collagen synthesis, angiogenesis, wound healing, and tissue remodeling. Widely studied within dermatology and regenerative medicine.
Clinical Rationale:
The GLOW Protocol expands upon the Wolverine Protocol by incorporating GHK-Cu to enhance collagen formation, tissue tensile strength, and overall regenerative signaling—particularly relevant for surgical recovery and joint replacement populations.
Safety, Oversight & Compliance
- Prescribed by a licensed medical provider
- Dispensed through FDA-registered 503A or 503B compounding pharmacies
- Individualized and conservative dosing protocols
- Used off-label; not FDA-approved for disease treatment
- No claims regarding diagnosis, cure, or prevention of disease
Selected Literature & References
- Sikiric P, et al. Stable gastric pentadecapeptide BPC-157: mechanisms and therapeutic potential. Curr Pharm Des. 2011.
- Chang C, et al. Angiogenic and wound healing effects of BPC-157. J Physiol Pharmacol. 2016.
- Goldstein AL, Kleinman HK. Thymosin beta-4: actin-sequestering protein regulating tissue repair. Ann NY Acad Sci. 2010.
- Malinda KM, et al. Thymosin beta-4 accelerates wound healing. J Invest Dermatol. 1999.
- Pickart L. The human tripeptide GHK and tissue remodeling. J Biomater Sci Polym Ed. 2008.
- Maquart FX, et al. Stimulation of collagen synthesis by copper peptides. Connect Tissue Res. 1993.
Faq’s
Are these peptides FDA-approved?
How are these therapies intended to be used clinically?
What is the proposed mechanism of action?
Which patients may be appropriate candidates?
How are peptides administered?
What is the role of Twin Rivers PT & Wellness?
What safety data exists?
Are there contraindications?
How does this integrate with physical therapy?
Are outcome claims being made?
Resources
- Meet Dr. Broussard/What to expect for patients: https://www.skool.com/asher-med/classroom/0af34434?md=3dbfa0dce3174e3ea4692fe7a3195c82
- https://www.wolverinepeptidestack.com/wolverine-stack-for-rotator-cuff-tears-shoulder-injuries/
- TRPT Peptide Menu